ヘモネティクスマルチコンポーネントシステムによる末梢血幹細胞採取

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The purpose of this study was to evaluate our experience with peripheral blood stem cell (PBSC) collection using the Haemonetics Multi Component System (Multi), a discontinuous flow cell separator with a third pump for concentrating harvested cells PBSCs were collected 12 times from 5 adults with malignant diseases Mononuclear cells (MNCs) were collected during 12-18 draw-and return cycles including 3-4 concentration procedures The PBSC procedure last-ed 259.9 ± 37.9 minutes on average We processed 101.0 ± 15.2 ml/kg of whole blood to obtain a final product of 106.3±20 6 ml, and obtained a mean yield of 2.86 ± 0.75 × 10^8/kg for nucleated cells, 2.64±0.80 × 10^8/kg for MNCs, and O.79±0.93 × 10^6/kg for CD 34^+ cells The collection efficiency percent of MNCs and CD 34^+ cells were 195.8±127.6, and 102.5±41.9%, respectively In addition, we compared these data with the data of 11 leukapheresis products collected from 5 adults on the Cobe Spectra in our hospital The number of MNCs and CD 34^+ cells collected by the Multi or Spectra, and the collection efficiency of MNCs and CD 34^+ cells for each instrument was not significantly different Our experience suggests that the cell separator has some advantages The Multi is easily moved, operates with a single vascular access, is fully automated, and runs very quietly

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