I-protein, a new regulatory protein from vertebrate skeletal muscle. III. Function.:III. Function

J-STAGE
  • MARUYAMA Koscak
    Department of Biophysics, Faculty of Science, University of Kyoto
  • KUNITOMO Sachio
    Department of Biophysics, Faculty of Science, University of Kyoto
  • KIMURA Sumiko
    Department of Biophysics, Faculty of Science, University of Kyoto
  • OHASHI Kazuyo
    Department of Biophysics, Faculty of Science, University of Kyoto

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説明

I-protein inhibited the Mg-activated ATPase [EC 3. 6. 1. 3] activity of actomyosin by approxi-mately 50% at low ionic strength. Concomitantly, the onset of superprecipitation was re-tarded. I-protein was found to bind to myosin, but not to F-actin.<br> The inhibitory action of I-protein occurred only in the absence of Ca ions in the troponin-tropomyosin-actin-myosin system. Addition of Ca ions abolished the effect. Thus, it is very likely that I-protein prevents unnecessary hydrolysis of ATP in the relaxed state of muscle.

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