STUDIES ON THE ACTION-PATTERN OF ANTITUBERCULAR SUBSTANCES:IV. ON THE METABOLISM OF MALONIG ACID BY MYCOBACTERIUM TUBERCULOSIS AVIUM

J-STAGE
  • HORIO TAKEKAZU
    Department of Biology, Faculty of Science, University of Osaka
  • OKUNUKI KAZUO
    Department of Biology, Faculty of Science, University of Osaka

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Description

1. The metablism of malonate was investigated using the cell suspension of Mycobacterium tuberculosis avium.<br> 2. The cell suspension oxidizes malonate, which is at first step decarboxylated into acetate.<br> 3. The enzyme taking part in the decarboxylation is an adaptive enzyme, the formation of which in the streptomycin-sensitive cells is inhibited in the presence of Streptomycin.<br> 4. The cell suspension of the streptomycin-resistant substrain oxidizes adaptively malonate and benzoate along S-shaped curves similar to the streptomycin-sensitive cells and these oxidations are not inhibited in the presence of Streptomycin.

Journal

  • J Biochem (Tokyo)

    J Biochem (Tokyo) 41 (6), 717-723, 1954

    The Japanese Biochemical Society

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