Studies on the Substrate Specificity of Taka-amylase A:VII. Synthesis of Some Analogues of Phenyl α-Maltoside and Enzymatic Investigation

ARITA Hitoshi, IKENAKA Tokuji, MATSUSHIMA Yoshio

Studies on the Substrate Specificity of Taka-amylase A:VII. Synthesis of Some Analogues of Phenyl α-Maltoside and Enzymatic Investigation

J-STAGE

ARITA Hitoshi

The Department of Chemistry, Osaka University College of Science
IKENAKA Tokuji

The Department of Chemistry, Osaka University College of Science
MATSUSHIMA Yoshio

The Department of Chemistry, Osaka University College of Science

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説明

Three analogues of phenyl α-maltoside which is a long known synthetic substrate of Taka-amylase A [EC 3. 2. 1. 1] were synthesized. Two of the new compounds, phenyl 2-O-methyl-α-maltoside and phenyl 2-deoxy-α-maltoside were found to be not susceptible to the enzyme. They showed considerable inhibitory action against the enzyme when phenyl α-maltoside was used as a substrate. One of the new compounds, phenyl 4-O-α-glucosyl-α-mannoside, was also found to be immune to the enzyme. Rather amazingly, the last compound showed no inhibitory action against the enzyme.