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Description
Summary 1. Radioactive L-aspartic acid was produced by incubating C i*-N-acetyl-L-aspartic acid with a mouse brain homogenate. 2. Glutathione and Co++ must co-exist to activate this reaction. However, the reaction could be performed more or less by using Fe++, Cu++, Ca++, and Zn*+ instead of Co*H. 3. The optimal pH of the reaction was 7.0. 4. The reaction took place not only in the brain of the mouse but also in the human, cat, hamster and rabbit brains, and there was not any significant difference among the activities in these different species. 5. The reaction was performed not only in the brain, but in the kidney, the liver and the spleen; the liver and spleen showing more activity than the brain, and the kidney at the most. 6. The investigation of the activities by the fractionation of the brain homogenate by ultra-centrifugation revealed that the reaction is remarkable in the supernatant of 18,00OXg centrifugation.
Journal
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- Psychiatry and Clinical Neurosciences
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Psychiatry and Clinical Neurosciences 15 4-9, 1961-04-01
Wiley
