A surface-bound form of human C1 esterase inhibitor on xenografts: the complement regulatory function
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説明
THE PURPOSE of the present study was to investigate the effect of the C1 esterase inhibitor (C1-INH), on a swine endothelial cell (SEC) membrane against human complement attack. Human C1-INH functions as an inhibitor for the complement reaction at the first step of the classical pathway in the fluid phase. The basic function of the transfected molecules on the xenosurface was investigated using Chinese hamster ovary (CHO) transfectants for the sake of convenience. The efficacy of C1-INH-mediated protection of SEC from human complement was then assessed as an in vitro hyperacute rejection model of a swine to human discordant xenograft.
収録刊行物
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- Transplantation Proceedings
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Transplantation Proceedings 32 901-902, 2000-08-01
Elsevier BV