Isolation of iturin A-2 as an inhibitor of cytokinesis of starfish embryos

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Abstract 1. 1. We have purified substances from the bacterium Bacillus subtilis that inhibit the cell division of embryos of the starfish, Asterina pectinifera , and which are identified as iturin A-2 and closely related cyclic peptides. 2. 2. Iturin A-2 at a concentration of 12.5 μg/ml or greater inhibited cell division of the fertilized starfish egg but not nuclear division, resulting in formation of a multinueleated unicellular embryo. 3. 3. Iturin A-2 microinjected into a fertilized egg was ineffective in halting cell division. 4. 4. From the results of these experiments, we conclude that the arrest of cleavage produced by iturin A-2 is due to the inability of the cell membrane to make a furrow at cytokinesis.

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