Volume Properties of Decylammonium Chloride and Micelle-Forming Local Anesthetic Mixtures in the Micelle

Ikuo Ueda, Hiroshi Kamaya, Michio Yamanaka, Hitoshi Matsuki, Shoji Kaneshina

doi:10.1021/la971385a

The densities of aqueous solutions of a decylammonium chloride (DeAC)−dibucaine hydrochloride (DC·HCl) mixture and a DeAC−tetracaine hydrochloride (TC·HCl) mixture were measured as a function of the total molality and composition of the mixture at 298.15 K under atmospheric pressure. The molar volumes of the mixture in the monomeric and micellar states of both systems were evaluated by applying the thermodynamic equations to the apparent molar volumes obtained from the density data. They varied linearly with composition between the values of pure components. The volume of mixed micelle formation also showed the linear dependence on the composition. These facts indicate that the DeAC and the anesthetic molecules mix ideally in both the monomeric and micellar states from the viewpoint of volume. On the other hand, the micellar composition was calculated from the composition dependence of the critical micelle concentration values. The shape of the phase diagram of micelle formation was slightly distorted cig...

Volume Properties of Decylammonium Chloride and Micelle-Forming Local Anesthetic Mixtures in the Micelle

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