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説明
1. When pheniprazine, a monoamine oxidase inhibitor, was administered to cats immobilized with gallamine triethiodide and maintained on artificial respiration, a continuous low voltage fast wave pattern in the corticogram and continuous 3–5 c/sec rhythmic activities in the hippocampus were observed. These changes lasted for more than several hours. 2. From the results obtained in truncated preparations (encephale isole and cerveau isole), the arousal effect on the EEG was shown to be due to the sustained activating influence of pheniprazine on the reticular formation. 3. Analysis of the effects of ten monoamines and sixteen amino acids showed that the effect of pheniprazine on the EEG could be attributed to the increase in the cerebral concentration of catecholamines and β-phenylethylamine derived from l-dopa and l-phenylalanine.
収録刊行物
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- Psychopharmacologia
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Psychopharmacologia 6 368-387, 1964-01-01
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