Fluorine-Containing Allenylpalladium Complexes. Synthesis of Optically Active Fluoroalkylated Allenes and Furan Derivatives
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説明
<jats:p>The reaction of fluoroalkylated propargyl mesylates with various nucleophiles, such as zinc reagents and enolates derived from 1,3-dicarbonyl compounds, in the presence of a palladium catalyst was investigated in detail. Various zinc reagents participated in the coupling reaction to give the corresponding fluoroalkylated allenes in good yields. When chiral mesylates were employed, the corresponding optically active allenes were obtained without any loss of enantiomeric purity in the reaction. On the other hand, treatment of trifluoromethylated propargyl mesylate with stabilized carbanions derived from methyl acetoacetate, acetylacetone, and diethyl malonate afforded fluorine-containing furan derivatives in moderate to high yields. </jats:p>
収録刊行物
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- Collection of Czechoslovak Chemical Communications
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Collection of Czechoslovak Chemical Communications 67 1421-1435, 2002-01-01
Institute of Organic Chemistry & Biochemistry
