Effects of FK506 on rat thymic microenvironment in thymocyte maturation, proliferation, and mobilization
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説明
THYMOCYTES are divided into four major populations: CD4CD8, CD4CD8, CD4CD8, and CD4CD8 thymocytes. Immature thymocytes develop into mature thymocytes through the expression of T cell receptors (TCR). These developmental sequences in phenotypic and TCR expression are considered important for the production of mature thymocytes. FK506 or Tacrolimus, which is a macrolide antibiotic produced by Streptomyces tsukubaensis, is a strong immunosuppressant drug that has been widely used for renal and other organ transplantations. In several studies it has been observed that FK506 also affects the thymus in rodent models. We have analyzed and reported the effects of FK506 on rat thymocytes using immunohistochemical stainingand 3–color flow cytofluorometry. In this study we also investigated and presented the effects of FK506 on rat thymic tissues analyzing the vascular structures in the thymus.
収録刊行物
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- Transplantation Proceedings
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Transplantation Proceedings 30 3600-3602, 1998-11-01
Elsevier BV