FRI0141 Retention Rate and Discontinuation Due to Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis Receiving Adalimumab Therapy: A Multicenter Study

Objectives We evaluated retention rate and discontinuation due to efficacy and safety of Adalimumab (ADA) in Japanese patients with rheumatoid arthritis (RA) in daily practice. Methods All RA patients (n=476) who underwent ADA treatment in the multicenter study group TBCR (Tsurumai Biologics Communication Registry) were enrolled in this study (Table1). Kaplan-Meier curves were generated to estimate the continuation rate and probabilities for therapy discontinuation, and discontinuation for different baseline characteristics were compared using the cox proportional hazards regression analysis. The sensitivity and specificity for the best cut-off rate was analyzed by a receiver-operated characteristic (ROC) curve. An incidence of adverse event (AE) was examined using per 100 patient-years (PY). Results The continuation rate of ADA therapy was 46% at 5 years. 116 patients discontinued ADA because of insufficient efficacy. Targeting the insufficient effective example, baseline previous use of biologics was a significant risk factor (hazard ratio [HR] 1.89, 95% confidence interval [CI] 1.13-3.17, p Conclusions The continuation rate of ADA therapy was 46% at 5 years. We considered concomitant MTX use is necessary in the long-term stable effectiveness of ADA therapy. Disclosure of Interest Y. Hattori Grant/research support from: Chugai Pharma Corporation, Pfizer, Abbvie, UCB, Bristol-Myers Squibb Janssen Pharma, and Nichi-Iko Pharmaceutical Corporation., A. Kaneko Grant/research support from: Chugai Pharma Corporation, Pfizer, Abbvie, UCB, Bristol-Myers Squibb Janssen Pharma, and Nichi-Iko Pharmaceutical Corporation., D. Kida Grant/research support from: Chugai Pharma Corporation, Pfizer, Abbvie, UCB, Bristol-Myers Squibb, Janssen Pharma, and Nichi-Iko Pharmaceutical Corporation., Y. Hirano Speakers bureau: Abbvie, Eisai Corporation, Mitsubishi Tanabe Pharma Corporation, Takeda Pharma Corporation, Pfizer, Chugai Pharma Corporation, and Bristol-Myers Squibb., T. Fujibayashi: None declared, N. Takahashi Speakers bureau: Abbvie, Eisai Corporation, Mitsubishi Tanabe Pharma Corporation, Pfizer, Chugai Pharma Corporation, and Bristol-Myers Squibb., K. Terabe: None declared, H. Kanda Grant/research support from: Chugai Pharma Corporation, Pfizer, Abbvie, UCB, Bristol-Myers Squibb, Janssen Pharma, and Nichi-Iko Pharmaceutical Corporation., T. Kojima Speakers bureau: Takeda Pharma Corporation, Janssen Pharmaceutical, Astellas Pharma Corporation, Mitsubishi Tanabe Pharma Corporation, Takeda Pharma Corporation, Eisai Pharma Corporation, Abbvie, Bristol-Myers Squibb, Pfizer, and Chugai Pharma Corporation, N. Ishiguro Speakers bureau: AbbVie, Chugai Pharma Corporation, Mitsubishi Tanabe Pharma Corporation, Daiichi-Sankyo, Eisai Pharma Corporation, Pfizer, and Takeda Pharma Corporation.