Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor ?
書誌事項
- 公開日
- 1993-07-01
- DOI
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- 10.1007/bf01218421
- 公開者
- Springer Science and Business Media LLC
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説明
The expression of mRNAs for epidermal growth factor (EGF), transforming growth factor alpha(TGF alpha), EGFR, platelet-derived growth factor (PDGF) A and B chain, PDGF receptor (PDGFR), transforming growth factor beta (TGF beta), erbB-2 and estrogen receptor (ER) genes was first examined in 6 human esophageal carcinoma cell lines, 6 xenoplanted and 15 surgically resected esophageal carcinomas. Secondly, the effect of EGF and TGF alpha on the expression of these genes by the TE-1 esophageal carcinoma cell line was investigated. The expression of EGF mRNA was detected in 8 (29.6%) of 27 tumors including the cell lines, whereas the TGF alpha and EGFR genes were expressed in 21 (77.8%) and 24 (88.9%) tumors respectively. PDGF B chain and PDGFR were detected in 18 (66.7%) and 20 (74.1%), respectively, and ER mRNA was observed in 16 (59.3%) tumors. Genes for PDGF A chain and TGF beta and the erbB-2 gene were commonly expressed. On the other hand, exogenous EGF and TGF alpha stimulated the expressions of fos and myc genes by TE-1 cells. The expression of mRNAs for TGF alpha, PDGF A and B chain and the erbB-2 genes was also increased after treatment with EGF. TGF alpha increased the accumulation of mRNAs for EGF, TGF alpha, EGFR, PDGF A and B chain and the erbB-2 gene. Moreover, the expression of mRNAs for interstitial collagenase, stromelysin and type IV collagenase was increased after EGF or TGF alpha treatment. These results indicate that EGF and TGF alpha may regulate the multi-growth-factor receptor expression and may play a central role for tumor invasion and metastasis as autocrine modulators for human esophageal carcinoma.
収録刊行物
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- Journal of Cancer Research and Clinical Oncology
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Journal of Cancer Research and Clinical Oncology 119 401-407, 1993-07-01
Springer Science and Business Media LLC
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キーワード
- Adult
- Male
- Platelet-Derived Growth Factor
- Epidermal Growth Factor
- Esophageal Neoplasms
- Metalloendopeptidases
- Adenocarcinoma
- Middle Aged
- Transforming Growth Factor alpha
- ErbB Receptors
- Gene Expression Regulation, Neoplastic
- Receptors, Estrogen
- Transforming Growth Factor beta
- Carcinoma, Squamous Cell
- Humans
- Female
- Receptors, Platelet-Derived Growth Factor
- RNA, Messenger
- Aged
詳細情報 詳細情報について
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- CRID
- 1870302167610080640
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- ISSN
- 14321335
- 01715216
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- PubMed
- 8491760
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- 本文言語コード
- en
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- データソース種別
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- OpenAIRE