A modified benzhydrylamine - A useful handle reagent for Fmoc based solid phase synthesis of peptide amides
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説明
<jats:p>Usefulness of a dimethoxybenzhydrylamine derivative, 3-(3-(Fmoc-amino-4-methoxyphenylmethyl)-4-methoxyphenyl)propionic acid, for Fmoc-based solid phase synthesis of peptide amides was demonstrated by preparation of three biologically active peptide amides, i.e. tetragastrin, neuromedin B and [8-arginine]vasopressin. 1M trimethylsilyl bromide-thioanisole (molar ratio 1 : 1) in trifluoroacetic acid was recommended as a deprotecting reagent for releasing the peptide amides from the resin.</jats:p>
収録刊行物
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- Collection of Czechoslovak Chemical Communications
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Collection of Czechoslovak Chemical Communications 53 2791-2800, 1988-01-01
Institute of Organic Chemistry & Biochemistry