STUDIES ON THE PROTEIN-BOUND POLYSACCHARIDE HEXOSE (PBP) OF THE CEREBROSPINAL FLUID IN NEUROPSYCHIATRIC FIELD: Survey in Epilepsy, Manic-Depressive and Other Psychosis Cases

Summary Following the preceding report of this Clinic, the CSF-PBP was measured in 63 cases of various kinds of psychopathics, and the following results were obtained. 1 Out of 35 cases of epilepsy, 29 cases (82.9%) showed increase in PBP value. The range of the values read 7–18 mg/L. with the mean value of 12.0 ± 3.06 mg/L. The values within the normal limits in 6 cases were more centered towards the normal maximum. As a whole, epileptic cases showed slight (16 cases) and moderate (13 cases) increase of the value. 2 5 cases of manic-depessive psychosis gave the values over the normal maximal limit. The range of the value read 9–12 mg/L, with the mean at 10.6 ± 1.10 mg/L. 3 In almost all the cases of atypical psychosis (4 cases), traumatic neurosis (8 cases) and alcohol intoxication, all the values fell within normal limits delivering insignificant difference from that of the control. 4 The range of values concerning 6 cases of cerebral arteriosclerosis read 9–18mg/L with the mean at 13.7±2.76 mg/L. 2 cases gave slight increase and 4 moderate increase. 5 Concerning the ratio of CSF-PBP against total liquor protein, it lets detect in every psychosis types the tendency toward increase in comparison with that of the control cases, especially marked was the tendency in manic state of manic-depressive psychosis and GM-group of epilepsy. 6 From the above, it seems more than likely that variation of the CSF-PBP fell in a wide range not only concerning cases of the organic psycho-neurological diseases with tissue destruction or tissue proliferation but was alsa deeply influenced by such functional factors, whether in metabolic or in endocrine disorders.