Interactions between endogenous L-DOPA and GABAA systems for cardiovascular control in the rat nucleus tractus solitarii.
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説明
Depressor responses to L-DOPA 30 ng microinjected into depressor sites were inhibited by GABA 3–30 ng and by nipecotic acid 100 ng whereas potentiated by bicuculline 10 ng. By microdialysis, basal L-DOPA release was reduced by muscimol 10 to 30 μM perfused via a probe by 50–60% whereas increased by bicuculline 30 μM by 40%. Pressor responses to 300 ng GABA were reduced by 50% by a competitive L-DOPA antagonist, L-DOPA methyl ester 1 μg. Meanwhile, L-DOPA 1–100 nM perfused released GABA by 35–60%. This release was not mimicked by D-DOPA and dopamine 10 nM, not affected by inhibition of central DOPA decarboxylase, and was markedly reduced by Ca2+ deprivation or tetrodotoxin 1μm.
収録刊行物
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- Japanese Journal of Pharmacology
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Japanese Journal of Pharmacology 71 24-, 1996-01-01
Elsevier BV
