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Description
A study of the ability of exogenous human chorionic gonadotropin (HCG) to inhibit ovulation is presented. 5 young women with regular menstrual cycles received injections of Primogonyl (HCG) in doses of 1000-5000 IU daily for 3-16 days. Ovulation was suppressed in 1 of 3 women taking the lowest does and in both women taking higher doses. The ovarian histology of the subjects showed marked luteinization of both granulosa and theca with various stages of atresia in most of the medium and large follicles. Successful suppression of ovulation appeared to be dose related and was dependent on the duration and timing of the injections. It is suggested that a hormonal mechanism may be involved in the induction of follicle atresia in the normal menstrual cycle.
Journal
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- Fertility and Sterility
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Fertility and Sterility 20 840-848, 1969-09-01
Elsevier BV
