A Convenient Synthesis of Coumarins by Palladium(II)-Catalyzed Reaction of Phenols with Propiolic Acids

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Description

A direct route to coumarin derivatives from phenols and propiolic acids has been developed. Phenols react with propiolic acids in the presence of Pd(OAc) 2 as a catalyst to give coumarins in good yields. The simple process occurs under mild conditions without any additives.

Journal

  • Synthesis

    Synthesis 2004 1466-1470, 2004-01-01

    Georg Thieme Verlag KG

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