Unconventional Ligand‐to‐Catalyst Ratio for the Distal C−C Bond Formation via C−H Activation and Chain‐Walking
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>A mechanism‐navigated enantioselective alkylation of an indole C2 C−H bond with an internal alkene was developed. Under the unconventional ligand‐to‐metal catalyst ratio, a moderate enantiomeric ratio (er), ranging from 70:30 to 88:12, was achieved with our original ligand. We propose that chain‐walking and bond formation are mechanistically independent and suggest that hydridoiridium generated from the C−H source does not play a role in the chain‐walking process.</jats:p>
収録刊行物
-
- Advanced Synthesis & Catalysis
-
Advanced Synthesis & Catalysis 366 3610-3615, 2024-08-07
Wiley