Clinical outcomes of left upper segmentectomy vs. lobectomy for early non-small-cell lung cancer: a nationwide database study in Japan

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<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Given that left upper lobe and right upper and middle lobes share a similar anatomy, segmentectomy, such as upper division and lingulectomy, should yield identical oncological clearance to left upper lobectomy. We compared the prognosis of segmentectomy with that of lobectomy for early stage non-small-cell lung cancer (NSCLC) in the left upper lobe.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We retrospectively examined 2115 patients who underwent segmentectomy or lobectomy for c-stage I (TNM 8th edition) NSCLC in the left upper lobe in 2010. We compared the oncological outcomes of segmentectomy (<jats:italic>n</jats:italic> = 483) and lobectomy (<jats:italic>n</jats:italic> = 483) using a propensity score matching analysis.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>The 5-year recurrence-free and overall survival rates in the segmentectomy and lobectomy groups were comparable, irrespective of c-stage IA or IB. Subset analyses according to radiological tumor findings showed that segmentectomy yielded oncological outcomes comparable to those of lobectomy for non-pure solid tumors. In cases where the solid tumor exceeded 20 mm, segmentectomy showed a recurrence-free survival inferior to that of lobectomy (<jats:italic>p</jats:italic> = 0.028), despite an equivalent overall survival (<jats:italic>p</jats:italic> = 0.38).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Segmentectomy may be an acceptable alternative to lobectomy with regard to the overall survival of patients with c-stage I NSCLC in the left upper lobe.</jats:p> </jats:sec>

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  • Surgery Today

    Surgery Today 54 1162-1172, 2024-04-18

    Springer Science and Business Media LLC

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