FK 506 abrogates induction of regulatory cells after intratracheal delivery of alloantigen
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説明
IT HAS BEEN reported that one conventional immunosuppressant FK 506, prolongs allograft survival. However, the effects of the drug on interactions leading to induction of regulatory mechanisms remain unclear. We previously reported that intratracheal delivery of donor splenocytes could induce prolonged survival of a fully allogeneic cardiac graft, resulting in the generation of regulatory cells. Using this model, we examined the influence of FK 506 on the induction of regulatory cells after intratracheal delivery of alloantigen.
収録刊行物
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- Transplantation Proceedings
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Transplantation Proceedings 34 1445-, 2002-08-01
Elsevier BV