Molecular docking analysis of stachydrine and sakuranetin with IL-6 and TNF-α in the context of inflammation
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説明
<jats:p>Inflammatory is cascade process triggered by pro-inflammatory cytokines and anti-inflammatory. In the present study anti-inflammatory activity of Stachydrine and Sakuranetin were studied against the inflammatory target proteins IL-6 and TNF-α by using molecular docking analysis. Both compounds showed the good binding with selected target proteins. Compared to Sakuranetin, the Stachydrine have lowest binding energy and good hydrogen bond interactions. Hence results of study indicated that Stachydrine possessed high and specific inhibitory activity on tumor necrosis factor-α and interleukin-6.</jats:p>
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- Bioinformation
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Bioinformation 17 348-355, 2021-02-28
Biomedical Informatics