Axonal Guillain-Barré syndrome subtypes

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Guillain-Barre syndrome (GBS) has been classified on a pathologic basis into demyelinating and axonal forms. Axonal GBS has been classified further into two groups: acute motor axonal neuropathy (AMAN) and acute motor and sensory axonal neuropathy (AMSAN).1 The principal clinical method for distinguishing AMAN, AMSAN, and acute inflammatory demyelinating polyneuropathy (AIDP) is electrodiagnostic, and clear criteria have been formulated.2,3⇓ The pathology of AMAN and AMSAN are very similar, and both conditions may follow Campylobacter jejuni enteritis.1 Anti-GM1, anti-GM1b, and anti-GD1a immunoglobulin (Ig)G antibodies can be used as immunologic markers to differentiate AMAN from AIDP, and patients with AMAN and AMSAN shared these autoantibodies.4 These data suggest that AMAN and AMSAN share a common …

Journal

  • Neurology

    Neurology 61 598-599, 2003-09-09

    Ovid Technologies (Wolters Kluwer Health)

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