Metabolic studies of bile acids. XLV1. The transformation of 3β,-7α-dihydroxychol-5-enic-24-14C acid to chenodeoxycholic acid in the rat. The significance of the C-7α-hydroxyl group in bile acid formation

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Abstract When 7α,12α-dihydroxy-3-oxocholanic-12β- 3 H acid and 7α-hydroxy-3-oxocholanic-7β- 3 H acid were administered to rats furnished with bile fistulas, cholic acid and chenodeoxycholic acid, respectively, were excreted in their bile. In addition, 3β,7α-dihydroxychol-5-enic-24- 14 C acid was converted to chenodeoxycholic acid. The significance of the C-7α-hydroxyl group in bile acid formation from cholesterol is discussed.

Journal

  • Steroids

    Steroids 3 147-161, 1964-02-01

    Elsevier BV

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