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Alteration in Ca2+/calmodulin-senshtve adenylyl cyclase activity in the hippocampus of stroke-prone spontaneously hypertensive rats
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Description
This study examined the function of adenylyl cyclase (AC) activity in the hippocampus and cerebral cortex of the stroke-prone spontaneously hypertensive rat (SHRSP). Male SHRSP (8-week-old and 25-week-old) were used for the experiments, and age-matched Wistar-Kyoto rats (WKY) were used as a genetic control. Basal, forskolin-, and GppNHp-stimulated AC activities were not different between SHRSP and WKY in the 8-week-old and 25-week-old groups. Ca2+/calmodulin-sensitive AC activity in hippocampal and cerebral cortex membranes was significantly lower in 25-week-old SHRSP than in age-matched WKY, but it was not in the 8-week-old group. These results suggest that the function of Ca2+/calmodulin-sensitive, presumably type I, AC was impaired in the brain of SHRSP. Such dysfunction of AC possibly contributes to the behavioral impairment reported in passive avoidance tasks in SHRSP.
Journal
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- Life Sciences
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Life Sciences 62 1683-1688, 1998-03-01
Elsevier BV