A Yeast Artificial Chromosome-Based Physical Map of the Juvenile Amyotrophic Lateral Sclerosis (ALS2) Critical Region on Human Chromosome 2q33–q34
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説明
The autosomal recessive form of juvenile amyotrophic lateral sclerosis (ALS2; RFALS Type 3) has previously been mapped to the 8-cM interval flanked by D2S115 and D2S155 on human chromosome 2q33-q34. We have established a yeast artificial chromosome (YAC) contig spanning an approximately 8-Mb region of the ALS2 candidate region and mapped 52 transcribed DNA sequences including 13 known genes and 39 expressed sequenced tags within this YAC contig. The establishment of a YAC contig and transcript map that spans the region containing the ALS2 mutation is an essential step in the identification of the ALS2 gene.
収録刊行物
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- Genomics
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Genomics 55 106-112, 1999-01-01
Elsevier BV