Optical resolution HPLC column packings carrying penicillin sulfoxide nucleus. Part IV. Effect of substituents in the benzyl ester group on the optical resolution efficiency
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説明
Fourteen new vinyl polymers carrying penicillin sulfoxide nucleus, poly (substituted-benzyl 1-oxo-6-metha-crylaminopenicillanate)s, were synthesized in order to investigate the influence of the substituents on the optical resolution capabilities. The resolution efficiency of the high-performance liquid chromatography columns comprising the obtained polymers were examined usingtrans-stilbene oxide and N-acetyl-1-phenethyl-amine. It was found that some columns resolved both racemates, some one, while the others did not separate either. A polymer which has 2,6-dichlorobenzyl moiety was found to resolve both racemates more effectively than the unsubstituted polymer.
収録刊行物
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- Chromatographia
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Chromatographia 28 513-515, 1989-11-01
Springer Science and Business Media LLC
