Induction and characterization of metallothionein in the liver and kidney of Japanese quail

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Abstract 1. 1. The low mol. wt cadmium-binding protein induced in the liver and kidney of Japanese quail by cadmium injection was a mixture of two isoproteins. 2. 2. The injection of cadmium induced the two isoproteins at a relative ratio of 6:1 regardless of single or multiple injections. 3. 3. The isoproteins had an apparent mol. wt of about 12,000 daltons and were abundant in half-cystine (36.8 and 38.3 mol%) without aromatic amino acids, indicating that the two isoproteins are metallothionein (MT). 4. 4. The major isoform, MT-II, contained one residue of histidine and the amino acid composition was similar to that of chicken metallothionein, while that of the minor isoform, MT-I, was slightly different from that of chicken.

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