Modification of evoked responses in cultured cortical networks

説明

Activity-dependent modification of evoked activity was studied using cultured cortical networks on electrode-array substrates. The novel multi-site stimulation system enabled the authors to observe pathway-specific enhancement and depression of network activity simultaneously induced by a single tetanus. Correlation analysis revealed that this bidirectional modification followed a common rule: how closely the individual pathways were correlated with the tetanized pathway.

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