Oligonuleotide Delivery with Dendritic Poly(L-lysine) for Treatments of the Liver Disorders

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<jats:title>Abstract</jats:title><jats:p>A cationic peptide dendrier, dendritic poly(L-lysine), forms complexes with oligonucleotides and can deliver them to liver after intravenous injection. Here, we tried to deliver apolipoprotein B-specific siRNA for the treatment of hypercholesterolemia and NFκB decoy for the hepatitis treatment. Significant therapeutic effects in those disease model mice were observed after intravenous injection of the oligonucleotides complexes with dendritic poly(L-lysine).</jats:p>

Journal

  • MRS Proceedings

    MRS Proceedings 1237 2009-01-01

    Springer Science and Business Media LLC

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