γ-Glutamylglutamine lactamase in mammalian tissues

Search this article

Description

Abstract An enzyme that catalyzes the degradation of γ- l glutamyl- l -glutamine to pyrrolidone carboxylic acid and glutamic acid has been purified I4-fold from an extract of acetone powder of rat liver. The substrate specificity of the enzyme preparation was examined on 9 γ-glutamyl peptides, 3α-glutamyl peptides, 4 dipeptides containing a glutamine residue in the carboxy terminal position, and 15 other compounds. Other properties of the enzyme are also described. This enzyme seems to be different from previously known peptidases and from γ-glutamyl lactamase, and is tentatively referred to as γ-glutamylglutamine lactamase. The distribution of the enzyme in various organs of the rat and guinea pig has been examined.

Journal

Details 詳細情報について

Report a problem

Back to top