Simultaneous high-performance liquid chromatographic determination of ciprofloxacin, fenbufen and felbinac in rat plasma

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Ciprofloxacin (CPFX) is a new quinolone agent with potent, broad antibacterial activity. It is well absorbed and widely distributed into various body tissues and fluids when given orally [1,2]. Recently, it was reported that severe convulsion was induced in some patients who were given new quinolone antibacterial agents and non-steroidal anti-inflammatory drugs, including fenbufen (FNB) [3,4], which was later reported to potentiate the convulsant activity of various quinolones in mice [5]. FNB is readily biotransformed into 4-biphenylacetic acid (felbinac, FLB), which possesses anti-inflammatory activity [6-81. Therefore, in order to investigate possible pharmacokinetic interaction between these drugs, it is necessary to develop a simple, sensitive, selective and simultaneous assay method for the quinolone, FNB and FLB in biological fluids. We have already developed high-performance liquid chromatographic (HPLC) methods for simultaneous determination of quinolone involving ofloxatin, enoxacin or norfloxacin with FNB and FLB [9-l 11, and examined the effects of FNB and FLB on the pharmacokinetics of these three quinolones [12-141. However, no investigation has been carried out on the pharmacokinetic interaction of the newer quinolone, CPFX, with FNB and FLB. This paper describes a novel analytical method for the simultaneous determination of CPFX, FNB and FLB in rat plasma.

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