Environmental Immunoamplifers for Allergy

Copyright: © 2012 Ken-ichiro Inoue, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The prevalence of allergic disorders has rapidly increased throughout the world [1,2] Alternation in environmental factors such as allergen load, infectious disease profile, vaccination, and the environmental adjuvants and so on, rather than genetic factors such as polymorphism, is likely to be regarded as the cause of this increase [3]. In relation to this, developed countries in which dramatic environmental change exist reportedly possess more populations of allergies than rural ones [3], although general allergens including insects and pollens are more abundant in urban areas. As for considering the moderate complex, it is implicated that environmental risk factors for immunotoxicity on allergy are epidemiologically, at least in part, attributable to environmental pollutants mainly produced/released from industries including endocrine disruptors like environmental estrogens (or xenoestrogens) as well as other factors as mentioned above. Nonetheless, there are few to scientifically prove the link between environmental chemicals and promotion/exacerbation of allergy.