Inhibitory Effect of an Anti-allergic Agent, TMK-688, on Interleukin-2 and Interleukin-4 Release by Mite Antigen-stimulated Monocytes From Peripheral Blood of Asthmatic Patients
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説明
The effect of an anti-allergic agent, TMK-688, which inhibits 5-lipoxygenase, on cytokine release by antigen-stimulated monocytes from peripheral blood of atopic asthmatic patients positive for mite antigen was studied. Monocytes were stimulated by mite antigen and then incubated for 72 h. The levels of interleukin-2 and interleukin-4 in the supernatant treated with TMK-688 (1 times 10−7 M) were significantly lower (P < 0.05 and P < 0.01, respectively) than levels in the untreated control. The findings suggest that TMK-688 is effective in treating bronchial asthma, as it not only inhibits 5-lipoxygenase but also has effects on T lymphocytes and inhibits various types of cytokine release.
収録刊行物
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- Pharmacy and Pharmacology Communications
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Pharmacy and Pharmacology Communications 5 403-405, 1999-06-01
Royal Pharmaceutical Society