P5463Hyperfiltration could be a risk factor for development of hypertension: A five-year cohort study

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Some recent studies showed that hyperfiltration is a risk for cardiovascular disease. However, the mechanism is still unknown. This longitudinal study tested the hypothesis that hyperfiltration could be a risk for hypertension.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>This study retrospectively included Japanese healthy adults between 30 and 85 years of age who had medical check-up at our Center for Preventive Medicine, both at enrollment (2004) and at 5-year follow-up (2009). We excluded the subjects with hypertension, diabetes mellitus, dyslipidemia, hyperuricemia, or chronic kidney disease (estimated glomerular filtration <60 mL/min/1.73 m2) at the baseline. We divided this study subjects into three categories of eGFR (60–80 (reference), 80–100, and 100≤mL/min/1.73 m2), and defined hyperfiltration as more than 100 mL/min/1.73 m2 of eGFR. We used logistic regression analyses to examine risk factors for development of hypertension with multiple adjustments for age, sex, smoking, drinking habits, body mass index, and eGFR categories.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>In this study, 6045 subjects without comorbidities (mean age of 47±10 years, 1,842 men) were followed for 5 years. Of those, 450 subjects had developed hypertension. After multiple adjustments, hyperfiltration is a risk for development of hypertension (OR: 1.374; 95% confidence incidence (CI), 1.013–1.864), as well as aging (OR: 1.063; 95% CI, 1.052–1.073), higher BMI (OR: 1.244; 95% CI, 1.200–1.289), and drinking habits (OR: 1.387, 95% CI, 1.117–1.721).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Hyperfiltration carries a significant risk for developing hypertension in Japanese individual without comorbidities. We should take account for hyperfiltration as a risk for hypertension, as well as chronic kidney diseases.</jats:p> </jats:sec>