Detection of Residual Lymph Node Metastases in High-Risk Papillary Thyroid Cancer Patients Receiving Adjuvant I-131 Therapy
書誌事項
- タイトル別名
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- The Usefulness of F-18 FDG PET/CT
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説明
The aims of this retrospective study were to evaluate the incidence of residual lymph node (LN) metastases in high-risk papillary thyroid cancer (PTC) patients receiving adjuvant I-131 therapy, especially in those without I-131 accumulation, and to evaluate the clinical usefulness of F-18 FDG PET/CT to detect those lesions.The 37 PTC patients receiving adjuvant I-131 therapy were retrospectively evaluated. We examined the incidence of residual LN metastasis and compared the accumulation of F-18 FDG and I-131 in those lesions, and compared the serum thyroglobulin (Tg) levels between patients with and without residual LN metastases.A total of 33 lesions were diagnosed as residual LN metastases in 9 patients. FDG accumulated in all of the lesions, but 19 lesions (57.6%) of them had no I-131 accumulation. The SUVmax was significantly higher in lesions without I-131 accumulation than in lesions with I-131 accumulation (6.6 +/- 2.8 vs. 4.2 +/- 1.8; P = 0.007). The serum Tg levels were significantly higher in patients with residual LN metastases than in patients without it (709.9 +/- 1470.8 vs. 25.6 +/- 37.1 ng/mL; P = 0.005). The incidence of residual LN metastasis was significantly higher in patients with a detectable serum Tg level than in patients without it (35.0% vs. 0%, P = 0.03).These results indicate that the residual LN metastasis was relatively common in high-risk PTC patients receiving adjuvant I-131 therapy whose serum Tg levels remained detectable, and those lesions often had no I-131 accumulation. FDG-PET/CT would be recommended for PTC patients with detectable serum Tg levels to detect residual LN metastases.
収録刊行物
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- Clinical Nuclear Medicine
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Clinical Nuclear Medicine 35 6-11, 2010-01-01
Ovid Technologies (Wolters Kluwer Health)
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キーワード
- Adult
- Male
- Sensitivity and Specificity
- Iodine Radioisotopes
- Fluorodeoxyglucose F18
- Humans
- Thyroid Neoplasms
- Radionuclide Imaging
- Aged
- Retrospective Studies
- Reproducibility of Results
- Middle Aged
- Carcinoma, Papillary
- Treatment Outcome
- Lymphatic Metastasis
- Subtraction Technique
- Female
- Radiotherapy, Adjuvant
- Neoplasm Recurrence, Local
- Radiopharmaceuticals
- Tomography, X-Ray Computed