Integral photodynamic therapy of superficial bladder tumors with mainly carcinoma in situ

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Whole bladder wall photodynamic therapy using hematoporphyrin derivative and argon-dye laser light 630 nm was performed on 40 patients with mainly carcinoma in situ of the bladder. Two types of laser light scattering diffuser developed at our department were used: motor-driven and endoscope-modified laser light scattering diffusers. The total energy density used was 10 to 30 Joules/cm 2 . Of the 40 patients, 29 (72.5%) achieved complete response and 5 (12.5%) partial response at 3 months follow-up. In 9 of the 40 patients there was no recurrence and average tumor-free time was 27.1 months, ranging from 12 to 84 months.

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