ULTRASTRUCTURE OF INCONTINENTIA PIGMENTI ACHROMIANS, WITH SPECIAL REFERENCE TO MELANOCYTES AND NERVE ENDINGS

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<jats:title>ABSTRACT</jats:title><jats:p>Studies of a new Japanese case of incontinentia pigmenti achromians were made by electron microscopy.</jats:p><jats:p>At the periphery of the depigmented lesions, the melanocytes had several subcellular abnormalities; <jats:italic>i.e</jats:italic>., vacuolization of the cytoplasm, aggregation of melanosomes, and autophagic vacuoles.</jats:p><jats:p>Many non‐specific basal dendritic cells could be identified as non‐pigment producing melanocytes. The depigmentation in this disease seemed to have been caused by both melanocyte degeneration and inactivation.</jats:p><jats:p>Numerous nerve endings were seen in close contact with the basal lamina of the epidermis or even within the epidermis.</jats:p><jats:p>Direct contacts between melanocytes and free nerve endings were presumed when a direct continuity between the Schwann cell basal lamina of the nerve ending and the basal lamina of melanocytes was observed.</jats:p><jats:p>It was further observed in this study that nerve endings could be found associated with either normal or degenerated melanocytes. Apparently normal melanocytes in the lesion may not be entirely normal in function.</jats:p>

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