Terminoside A, a new triterpene glycoside from the bark of<i>Terminalia arjuna</i>inhibits nitric oxide production in murine macrophages
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説明
Terminoside A (1), a new oleanane-type triterpene was isolated from the acetone fraction of the ethanolic extract of stem bark of Terminalia arjuna. The structure was established as olean-1alpha,3beta,22beta-triol-12-en-28-oic acid-3beta-D-glucopyranoside. On the basis of spectral data and chemical reactions, terminoside A, potently inhibited nitric oxide (NO) production and decreased inducible nitric oxide synthase (iNOS) levels in lipopolysaccharide-stimulated macrophages.
収録刊行物
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- Journal of Asian Natural Products Research
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Journal of Asian Natural Products Research 5 137-142, 2003-06-01
Informa UK Limited
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キーワード
- Spectrometry, Mass, Electrospray Ionization
- Plants, Medicinal
- omega-N-Methylarginine
- Optical Rotation
- Macrophages
- Nitric Oxide Synthase Type II
- Spectrometry, Mass, Fast Atom Bombardment
- Nitric Oxide
- Triterpenes
- Cardiac Glycosides
- Mice
- Spectroscopy, Fourier Transform Infrared
- Plant Bark
- Terminalia
- Animals
- Glycosides
- Nitric Oxide Synthase
- Nuclear Magnetic Resonance, Biomolecular