Antitumor Activity and Some Properties of Water-soluble Polysaccharides from “Himematsutake,” the Fruiting Body of<i>Agavicus blazei</i>Murill
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説明
Polysaccharides extracted from Himematsutake, the fruiting body of Agaricus blazei Murill with hot water were fractionated and purified by ethanol precipitation, ion-exchange chromatography, gel-filtration, affinity chromatography, etc.A total of 17 polysaccharide samples thus obtained were given an antitumor activity test (Sarcoma 180/mice i.p. p.o. method) and traces of their activities through the fractionation and purification processes were found.FI0-a-β, FA-1-a-β, FA-1-a-β, and FA-2-b-β, were obtained as water soluble polysaccharides fractions having great antitumor activities.Analyses of physico-chemical properties and IR- and NMR-spectra of these active fractions showed that their main components were: FI0-a-β, (1 → 6)-; (1 → 3)-β-d-glucan; FA-1-a-α, acidic (1 → 6)-; (1 → 4)-α-d-glucan; FA-1-a-β, acidic (1 → 6)-; (1 → 3)-α-d-glucan; and FA-2-b-β, acidic RNA-protein complex.
収録刊行物
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- Agricultural and Biological Chemistry
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Agricultural and Biological Chemistry 54 2889-2896, 1990-11-01
Oxford University Press (OUP)