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GABAc receptor model of retinal horizontal cells simulating emphasis of light-dark contrast
Description
We simulated the GABAc receptor model that has two functionally contrastive binding sites represented by Ca/sup 2+/ (facilitation) and Zn/sup 2+/ (inhibition) in the extracellular domain, and investigate the effect of GABAc receptors by extracellular Zn/sup 2+/. It was reported that Zn/sup 2+/ are colocalized with glutamatergic synaptic vesicles in photoreceptors in the light. We describe that the response of GABAc receptor is reduced by increasing the concentration of Zn/sup 2+/ caused by illumination and the modulatory action of Ca/sup 2+/ and Zn/sup 2+/ on GABAC receptor emphasis of contrast at a dark-light boundary.
Journal
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- Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)
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Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136) 5 2215-2217, 2002-11-22
IEEE