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Induction of protective antibody responses against pseudorabies virus by intranasal vaccination with glycoprotein B in mice
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Description
Intranasal vaccination of mice with glycoprotein B (gB) of pseudorabies virus (PRV) induced specific IgA and IgG antibody responses in the secretion of the respiratory tract, resulting in protection of the animals against intranasal challenge with a lethal dose of virulent PRV. The immune response was enhanced by the use of cholera toxin B subunit as an adjuvant. The present results indicate that local vaccination with gB is a promising strategy to confer protective immunity on animals against PRV infection by inducing secretory antibodies on their mucosal surfaces where the primary replication of the virus occurs.
Journal
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- Archives of Virology
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Archives of Virology 140 1629-1635, 1995-09-01
Springer Science and Business Media LLC