Enzymic synthesis of acyllysine anilides. I. Effect of acyl groups on the rate of anilide synthesis

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Abstract 1. 1. A number of α,ϵ- N,N′ -diacyl- dl -lysines are tested for their rates of anilide synthesis as catalyzed by papain. 2. 2. The varying combinations of α- and ϵ-acyl groups of the substrate influence the reactivity of the substrate as well as the yield of anilide. The latter variation is interpreted in terms of solubility of the anilide formed. 3. 3. The synthesis and characterization of more than ten new monoand diacyl- dl -lysines are described.

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