A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development

Ziva Misulovin, Jay Wayne, Kayo Inaba, Karen Sokol, Michel C. Nussenzweig, Heikyung Suh

doi:10.1016/1074-7613(94)90103-1

RAG-1 and RAG-2 are developmentally regulated genes that are essential for the assembly of antigen receptors in lymphoid cells. Here we describe transgenic mice that carry RAG-1 and RAG-2 under the control of the proximal lck promoter. Persistent expression of RAG-1 and RAG-2 was associated with incomplete thymopoiesis and profoundly compromised cellular immunity. In addition, RAG transgenic mice rapidly developed lymphadenopathy, splenomegaly, and lymphocytic perivascular infiltrates. These effects required both RAG-1 and RAG-2, since mice that carried either gene exclusively were indistinguishable from wild-type controls. We propose that in addition to a previously documented role in V(D)J recombination, RAG-1 and RAG-2 expression must be properly regulated for completion of normal T cell development

A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development

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A regulatory role for recombinase activating genes, RAG-1 and RAG-2, in T cell development

この論文をさがす

説明

収録刊行物

キーワード

詳細情報 詳細情報について

書き出し

問題の指摘

詳細情報詳細情報について