Histamine suppression of the non‐immunological release of slow reacting substances from neutrophils of asthmatics
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説明
<jats:title>Abstract</jats:title><jats:p>Slow reacting substance is released from cytochalasin B treated human polymorphonuclear leukocytes by incubation with zymosan and fresh autologous serum.</jats:p><jats:p>It is reversed by FPL 55712, a specific endorgan antagonist of SRS‐A and the process is confirmed to involve LTC<jats:sub>4</jats:sub>, LTD<jats:sub>4</jats:sub>, LTE<jats:sub>4</jats:sub> by High‐Performance Liquid Chromatography.</jats:p><jats:p>The levels of SRS from PMN by the non‐immunological stimuli are significantly higher in asthma group than in control group.</jats:p><jats:p>SRS is inhibited with pretreatment of theophylline and histamine, and the suppressed release of SRS is recovered by adding cimetidine, H2‐brocker.</jats:p><jats:p>Histamine appears to inhibit SRS release through H2‐receptor.</jats:p><jats:p>The role of neutrophils in IgE mediated hypersensitivity was discussed.</jats:p>
収録刊行物
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- Pediatrics International
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Pediatrics International 25 342-348, 1983-12-01
Wiley