Effect of substituent ribose of adenosine analogs on binding to the adenosine deaminase in the scallop (Patinopecten yessoensis) midgut gland
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説明
1. 1. The Km was 30 μM and the kcat was 120/sec for deamination of adenosine, and 11 analogs modified on the ribose moiety were substrates with specific values of both these parameters. 2. 2. The deamination rate of α-adenosine was extremely slow and four adenine nucleotides were neither substrates nor inhibitors. 3. 3. Adenosine 5′-carboxylic acid was not deaminated and did not act as an inhibitor at pH 6.0, but was measurably cleaved at pH 4.0. 4. 4. The other 13 analogs were competitive inhibitors.
収録刊行物
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- Comparative Biochemistry and Physiology Part B: Comparative Biochemistry
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Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 105 63-67, 1993-05-01
Elsevier BV