書誌事項
- 公開日
- 2012-07-01
- DOI
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- 10.1016/j.semnephrol.2012.06.006
- 公開者
- Elsevier BV
この論文をさがす
説明
Wnt/Ctnnb1 and Notch signaling play key roles in kidney development and epithelial cell specification. Recent reports have suggested that these pathways are reactivated in response to injury and in different disease conditions. Studies using genetically modified animal models showed that sustained activation of Notch and Wnt signaling in podocytes are causally related to albuminuria and glomerulosclerosis development. Here, we discuss the role and regulation of Wnt/Ctnnb1 and Notch signaling in podocytes.
収録刊行物
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- Seminars in Nephrology
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Seminars in Nephrology 32 350-356, 2012-07-01
Elsevier BV