- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- 【Updated on June 30, 2025】Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Roles of Endoplasmic Reticulum Stress in Neurodegenerative Diseases
Description
The accumulation of misfolded proteins disrupts the functioning of endoplasmic reticulum (ER), leading to induction of the unfolded protein response (UPR) that protect cells against the toxic buildup of such proteins. However, prolonged stress due to the buildup of these toxic proteins induces specific cell death pathways. There is accumulating evidence implicating ER stress in the development and progression of neurodegenerative diseases. With the improved understanding of the underlying molecular mechanisms, therapeutic interventions that target the ER stress response would be potential strategies to treat neurodegenerative diseases.
Journal
-
- Translational Medicine
-
Translational Medicine 02 2012-01-01
OMICS Publishing Group
- Tweet
Details 詳細情報について
-
- CRID
- 1871428068042549504
-
- ISSN
- 21611025
-
- Data Source
-
- OpenAIRE