Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides

Jia Wang, Sukant Garg, Huayue Zhang, Jaspreet Kaur Dhanjal, Ashish Kaul, Shubhra Agarwal, Vipul Kumar, Sudhanshu Vrati, Durai Sundar, Chandru Subramani, Renu Wadhwa, Rajkumar Singh Kalra, Sunil C. Kaul

doi:10.1016/j.ijbiomac.2021.06.015

Description

COVID-19 caused by SARS-CoV-2 corona virus has become a global pandemic. In the absence of drugs and vaccine, and premises of time, efforts and cost required for their development, natural resources such as herbs are anticipated to provide some help and may also offer a promising resource for drug development. Here, we have investigated the therapeutic prospective of Ashwagandha for the COVID-19 pandemic. Nine withanolides were tested in silico for their potential to target and inhibit (i) cell surface receptor protein (TMPRSS2) that is required for entry of virus to host cells and (ii) viral protein (the main protease M

Journal

International Journal of Biological Macromolecules

International Journal of Biological Macromolecules 184 297-312, 2021-08-01

Elsevier BV

Keywords

Details 詳細情報について

CRID: 1871428068060953088

DOI: 10.1016/j.ijbiomac.2021.06.015

ISSN: 01418130

PubMed: 34118289

Data Source

OpenAIRE

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