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Description
Summary 1 With and without electrical pulses, the action of mescaline on respiration of preparations of rat cerebral cortex in the presence of glucose was determined. 2 When electrical pulses were applied to the tissue of control, its respiration value increased about 1.6 times higher than that of the original value. But after the pulses were removed the value was restored to that of the resting state. 3 The respiration of tissue without electrical pulses was slightly inhibited at the concentration of 1O-2 M of mescaline, but did not show any effect at the concentrations of 3 × 10-3 M and 10-4 M, either. 4 Unexpectedly, there was no inhibition of extra uptake of oxygen of the tissue under the electrical pulses, even at the concentration as high as 10-2 M of mescaline. 5 After the pulses were removed, at the concentration of 10-3 M, 3 × 10-3 M, 10-2 M mescaline could inhibit the respiration to 22.7, 33.8 and 50.0 per cent respectively, compared with the control. 6 From these observations, it was suggested that some enzymes, which might act only on the resting state, might be disturbed by mescalin under coopzration in of stimulation of electrical pulses on the cerebral tissue.
Journal
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- Psychiatry and Clinical Neurosciences
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Psychiatry and Clinical Neurosciences 14 156-166, 1960-07-01
Wiley
